Royal Air Force Typhoon FGR4s have operated alongside France's air force in a combined operation on an underground arms cache in Syria employed by the Daesh militant organization, according to the UK's MoD.
The facility, pinpointed through surveillance, was believed to be housing weapons and explosive materials, the announcement noted, and was located in mountains just above Palmyra in Syria's central region.
"The RAF jets utilized Paveway IV guided bombs to hit a several approach shafts down to the depot... early reports indicate the target was engaged successfully," officials stated.
There was no sign of any harm to civilians in the strike on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
IS - referred to as Daesh - imposed jihadist rule over parts of Syria and Iraq prior to its 2019 collapse.
"This action demonstrates our UK leadership, and commitment to stand shoulder to shoulder with our allies, to eradicate any revival of the terrorist group and their harmful and extremist ideologies in the region," Britain's Defence Chief the minister said.
RAF aircraft have performed patrols over Syria to "deter any attempted resurgence" of Islamic State after its defeat at the Baghuz confrontation in the year 2019, the MoD reported.
"I want to thank every member of the UK armed forces involved in this mission for their expertise and their courage," he commented. "They were part of thousands of UK service members deployed over the holidays. This mission, to take out terrorist threats who pose a risk to our way of life, shows how UK forces are ready to step up, continuously, keeping Britain secure within its borders and strong abroad."
In December, the American forces conducted what it called a "major assault" on Islamic State objectives in Syria, after an attack claimed the lives of two American soldiers and a local interpreter in Palmyra.
The United Nations estimates IS still has roughly 5-7 thousand militants in Syria and Iraq.